In S1E2 we highlight a case report by Dr. Cody Mansfield entitled, Cervical myelopathy causing numbness and paresthesias in lower extremities: A case report identifying the cause of a false positive Sharp–Purser test. Differential diagnosis, the diagnostic accuracy and safety and appropriateness of utilizing the Sharp-Purser test are all major themes in this paper. Subscribers to the premium version will hear more details on this case, how this case prompted a systematic review of the Sharp-Purser test which we’ll highlight in S1E3, the big takeaways and additional studies which will further focus on screening for red flags, special test sensitivity, and other, related special tests.