In episode 1 of season 7 of Inside the Science, we’re highlighting the study, “Efficacy, Tolerability, and Dose-Dependent Effects of Opioid Analgesics for Low Back Pain” with Dr. Christina Abdel Shaheed. She shares some of what prompted this study, how patterns of prescribing opioids vary across the globe, some specifics on the studies included in this review, and how she would advise the reader who cares for patients with low back pain who are prescribed opioids might use this paper to advocate for their patient, the clinical implications and the big takeaways.