In episode 2 of season 6 of Inside the Science we’re highlighting the study, “Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis The RESTORE Randomized Clinical Trial” with Dr. David Hunter. He explains what the previous literature suggested about PRP injections, what the treatment is, technically and theoretically, proposed to do, how there are a lot of studies which have shown positive effects but that most of that data is of poor quality. He also shares the clinical implications for interventionists and conservative care clinicians and the big takeaways.