In episode 4 of season 6 of Inside the Science we’re highlighting the study, “Is a stepped-care intervention effective in overweight and obese people with medial tibiofemoral osteoarthritis? A randomised controlled trial” with Dr. David Hunter. He explains what prompted this work, how this study attempted to mimic clinical practice, why the criteria of subjects being obese was included, more on the methods, how subjects were stepped into the second phase, what qualified as disease remission, the clinical implications and the big takeaways.